Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 14/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417284 | 1.00 | HCRTR2 (0.41) | HCRTR2HCRTR1MAPK8PIK3CATLR8 | |
| SCHEMBL3411958 | 1.00 | HCRTR2 (0.41) | HCRTR2HCRTR1MAPK8PIK3CATLR8 | |
| SCHEMBL3412360 | 1.00 | HCRTR2 (0.41) | HCRTR2HCRTR1MAPK8PIK3CATLR8 | |
| SCHEMBL2799729 | 0.87 | POLB (0.38) | HCRTR2HCRTR1MAPK8PIK3CA | |
| SCHEMBL2801596 | 0.85 | HCRTR2 (0.44) | HCRTR2HCRTR1GRM5 | |
| SCHEMBL1341088 | 0.84 | HCRTR2 (0.44) | HCRTR2HCRTR1MAPK8GRM5 | |
| SCHEMBL3417288 | 0.84 | HCRTR2 (0.44) | HCRTR2HCRTR1MAPK8GRM5 | |
| SCHEMBL1340420 | 0.84 | HCRTR2 (0.44) | HCRTR2HCRTR1MAPK8GRM5 | |
| SCHEMBL3413481 | 0.84 | HCRTR1 (0.41) | HCRTR2HCRTR1PIK3CAGRM5 | |
| SCHEMBL2924872 | 0.83 | HDAC7 (0.36) | HCRTR2HCRTR1TLR8GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |