Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 9/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416676 | 0.89 | AR (0.49) | ARPGRALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3415498 | 0.88 | AR (0.48) | ARPGRKDM4EMEN1ALDH1A1 | |
| SCHEMBL3412694 | 0.87 | AR (0.48) | ARPGRMAPT | |
| SCHEMBL3417065 | 0.87 | AR (0.47) | ARPGR | |
| SCHEMBL3419681 | 0.87 | AR (0.47) | ARPGR | |
| SCHEMBL3417939 | 0.83 | AR (0.46) | ARPGRMEN1KMT2A | |
| SCHEMBL3418810 | 0.83 | AR (0.54) | ARPGR | |
| SCHEMBL3413754 | 0.83 | AR (0.48) | ARPGR | |
| SCHEMBL3418855 | 0.83 | AR (0.45) | ARPGR | |
| SCHEMBL3419404 | 0.82 | PLA2G7 (0.49) | ARPGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834063-B2 | 4-[(Cyclopropylmethyl)(2-{[4-(1,1-dimethylethyl)phenyl]oxy}ethyl)amino]-2-(trifluoromethyl)benzonitrile; modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors; osteoporosis, muscle wasting,endometriosis, cardiovascular disease; breast, uterine cancer, prostatic hyperplasia | GLAXOSMITHKLINE LLC (US) | 2010-11-16 | — | — | US | claimed |