Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340695 | 1.00 | HCRTR1 (0.42) | HCRTR1HCRTR2KCNH2CACNA1ICHRM1 | |
| SCHEMBL1340699 | 1.00 | HCRTR1 (0.42) | HCRTR1HCRTR2KCNH2CACNA1ICHRM1 | |
| SCHEMBL1339036 | 0.93 | HCRTR1 (0.49) | HCRTR1HCRTR2KCNH2CACNA1ICHRM1 | |
| SCHEMBL1339033 | 0.93 | HCRTR1 (0.49) | HCRTR1HCRTR2KCNH2CACNA1ICHRM1 | |
| SCHEMBL1338187 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2MEN1KMT2AOPRM1 | |
| SCHEMBL1338185 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2MEN1KMT2AOPRM1 | |
| SCHEMBL3431383 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2MEN1KMT2AOPRM1 | |
| SCHEMBL1340331 | 0.90 | HCRTR1 (0.42) | HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1340333 | 0.90 | HCRTR1 (0.42) | HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL3415595 | 0.86 | HCRTR1 (0.52) | HCRTR1HCRTR2MEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |