Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338187 | 1.00 | HCRTR1 (0.46) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL1338185 | 1.00 | HCRTR1 (0.46) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL1340949 | 0.94 | HCRTR1 (0.52) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL1340950 | 0.94 | HCRTR1 (0.52) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL3415595 | 0.94 | HCRTR1 (0.52) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL3415599 | 0.94 | HCRTR1 (0.52) | HCRTR1HCRTR2DRD4HPGDMEN1 | |
| SCHEMBL3413899 | 0.92 | HCRTR1 (0.42) | HCRTR1HCRTR2MEN1KMT2AOPRM1 | |
| SCHEMBL1340331 | 0.92 | HCRTR1 (0.42) | HCRTR1HCRTR2HPGDMEN1KMT2A | |
| SCHEMBL1340695 | 0.92 | HCRTR1 (0.42) | HCRTR1HCRTR2MEN1KMT2AOPRM1 | |
| SCHEMBL1340333 | 0.92 | HCRTR1 (0.42) | HCRTR1HCRTR2HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |