Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378894 | 0.86 | P2RX7 (0.43) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| SCHEMBL4646894 | 0.85 | P2RX7 (0.41) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| SCHEMBL4648735 | 0.82 | P2RX7 (0.39) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| SCHEMBL3380633 | 0.81 | P2RX7 (0.41) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| SCHEMBL4645798 | 0.81 | HRH3 (0.48) | MEN1KMT2AFAAHACHE | |
| Hydrochloric Acid SCHEMBL3379330 | 0.80 | P2RX7 (0.44) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL3379328 | 0.80 | P2RX7 (0.44) | L3MBTL1P2RX7MEN1KMT2ATP53 | |
| SCHEMBL3381143 | 0.80 | KDM4E (0.46) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3378843 | 0.80 | KDM4E (0.46) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4648242 | 0.79 | TP53 (0.41) | L3MBTL1P2RX7MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | disclosed |