Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531520 | 1.00 | PLK4 (0.58) | PLK4CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL6531516 | 1.00 | PLK4 (0.58) | PLK4CYP3A4CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL6530399 | 0.99 | PLK4 (0.57) | PLK4CYP3A4CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL6530403 | 0.99 | PLK4 (0.57) | PLK4CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL586527 | 0.89 | PLK4 (0.52) | PLK4CYP3A4CYP2C9CYP2C19AURKA | |
| SCHEMBL2548126 | 0.89 | PLK4 (0.52) | PLK4CYP3A4CYP2C9CYP2C19AURKA | |
| SCHEMBL2548124 | 0.89 | PLK4 (0.52) | PLK4CYP3A4CYP2C9CYP2C19AURKA | |
| Hydrochloric Acid SCHEMBL2549114 | 0.88 | PLK4 (0.51) | PLK4CYP3A4CYP2C9CYP2C19AURKA | |
| Hydrochloric Acid SCHEMBL589914 | 0.88 | PLK4 (0.51) | PLK4CYP3A4CYP2C9CYP2C19AURKA | |
| Hydrochloric Acid SCHEMBL2549115 | 0.88 | PLK4 (0.51) | PLK4CYP3A4CYP2C9CYP2C19AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402828-B2 | Methods of targeting PTEN mutant diseases and compositions therefor | UNIVERSITY HEALTH NETWORK (CA) | 2016-08-02 | — | — | US | disclosed |
| US-9402828-B2 | Methods of targeting PTEN mutant diseases and compositions therefor | UNIVERSITY HEALTH NETWORK (CA) | 2016-08-02 | — | — | US | disclosed |
| US-20150182504-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | UNIVERSITY HEALTH NETWORK (CA) | 2015-07-02 | — | — | US | disclosed |
| US-20150182504-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | UNIVERSITY HEALTH NETWORK (CA) | 2015-07-02 | — | — | US | disclosed |
| US-8933070-B2 | Methods of targeting PTEN mutant diseases and compositions therefor | UNIVERSITY HEALTH NETWORK (CA) | 2015-01-13 | — | — | US | disclosed |
| US-8933070-B2 | Methods of targeting PTEN mutant diseases and compositions therefor | UNIVERSITY HEALTH NETWORK (CA) | 2015-01-13 | — | — | US | disclosed |
| US-8765748-B2 | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer | UNIVERSITY HEALTH NETWORK (CA) | 2014-07-01 | — | — | US | disclosed |
| US-8765748-B2 | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer | UNIVERSITY HEALTH NETWORK (CA) | 2014-07-01 | — | — | US | disclosed |
| US-20130123273-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | UNIVERSITY HEALTH NETWORK (CA) | 2013-05-16 | — | — | US | disclosed |
| US-20130123273-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | UNIVERSITY HEALTH NETWORK (CA) | 2013-05-16 | — | — | US | disclosed |
| WO-2012000103-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | UNIVERSITY HEALTH NETWORK (CA) | 2012-01-05 | — | — | WO | disclosed |
| US-20110065702-A1 | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK | 2011-03-17 | — | — | US | disclosed |
| US-20110065702-A1 | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK | 2011-03-17 | — | — | US | disclosed |
| WO-2009079767-A9 | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009079767-A1 | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123273-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | PTEN, PIK3CA, HRAS | PLK4 23/4885CYP3A4 4869/4885CYP2C9 4882/4885 |
| US-20110065702-A1 | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | TNNI3K, ABL1, TK1 | PLK4 464/4885CYP3A4 3081/4885CYP2C9 2995/4885 |
| US-20150182504-A1 | METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR | PTEN, PIK3CA, HRAS | PLK4 139/4885CYP3A4 4872/4885CYP2C9 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.