Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411310 | 0.93 | KIT (0.44) | GRM5KITHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL3413088 | 0.93 | GRM5 (0.58) | GRM5KITHSP90AA1HSP90AB1 | |
| SCHEMBL3414617 | 0.92 | KIT (0.44) | GRM5KITHSP90AA1HSP90AB1 | |
| SCHEMBL3414822 | 0.89 | GRM5 (0.49) | GRM5KITHSP90AA1HSP90AB1 | |
| SCHEMBL3414781 | 0.86 | GRM5 (0.49) | GRM5KITHSP90AA1HSP90AB1 | |
| SCHEMBL3415240 | 0.86 | GRM5 (0.60) | GRM5KITHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL3413915 | 0.85 | GRM5 (0.46) | GRM5KITHSP90AA1HSP90AB1TRAP1 | |
| SCHEMBL4326377 | 0.85 | SLC6A7 (0.58) | — | |
| SCHEMBL3410361 | 0.84 | GRM5 (0.51) | GRM5KITHSP90AA1HSP90AB1 | |
| SCHEMBL3414939 | 0.84 | NAMPT (0.47) | GRM5KITHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100273772-A1 | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) | WYETH LLC (US) | 2010-10-28 | — | — | US | claimed |
| US-20100273772-A1 | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) | WYETH LLC (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273772-A1 | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) | GRM5, GRM1, GRM2 | GRM5 1/4885KIT 4672/4885HSP90AA1 4523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.