Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340795 | 0.89 | HCRTR1 (0.51) | HCRTR1HCRTR2ESR1MAPTMAPK10 | |
| SCHEMBL3416912 | 0.88 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3417609 | 0.88 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL3417926 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2KMT2A | |
| SCHEMBL3416094 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3418116 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2MAPTKDM4EALDH1A1 | |
| SCHEMBL3417726 | 0.85 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3415476 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL3415414 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2MTNR1AMTNR1B | |
| SCHEMBL3411422 | 0.82 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |