Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415450 | 0.93 | HCRTR1 (0.36) | HCRTR1HCRTR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3417926 | 0.89 | HCRTR1 (0.44) | HCRTR1HCRTR2LMNA | |
| SCHEMBL1340759 | 0.89 | HCRTR1 (0.48) | HCRTR1HCRTR2SMN1; SMN2LMNA | |
| SCHEMBL3416912 | 0.88 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3417726 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3416094 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3415069 | 0.86 | HCRTR1 (0.45) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL3411422 | 0.83 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3414514 | 0.82 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3415476 | 0.82 | HCRTR1 (0.42) | HCRTR1HCRTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |