Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415107 | 1.00 | GRM4 (0.39) | GRM4NUDT1GRM5LOXLOXL2 | |
| SCHEMBL16667809 | 0.91 | LRRK2 (0.43) | GRM4NUDT1GRM5LRRK2AKT1 | |
| SCHEMBL3416856 | 0.91 | LRRK2 (0.43) | GRM4NUDT1GRM5LRRK2AKT1 | |
| SCHEMBL3416862 | 0.91 | LRRK2 (0.43) | GRM4NUDT1GRM5LRRK2AKT1 | |
| SCHEMBL3411667 | 0.85 | NUDT1 (0.44) | NUDT1LOXLOXL2FEN1ALOX5AP | |
| SCHEMBL22834492 | 0.83 | LOX (0.46) | NUDT1LOXLOXL2LRRK2FEN1 | |
| SCHEMBL18072495 | 0.83 | LOX (0.50) | NUDT1LOXLOXL2LRRK2FEN1 | |
| SCHEMBL18072381 | 0.82 | HDAC6 (0.44) | GRM4NUDT1LOXLOXL2LRRK2 | |
| SCHEMBL31403582 | 0.82 | LOX (0.53) | NUDT1LOXLOXL2LRRK2FEN1 | |
| SCHEMBL24441036 | 0.80 | NUDT1 (0.47) | NUDT1LOXLOXL2FEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068863-A2 | PYRIMIDINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-06-17 | — | — | WO | claimed |