Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.36 |
| ▸ | CDK2 | P24941 | 9/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | PDE8A | O60658 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25211412 | 0.82 | P2RX7 (0.41) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL539356 | 0.76 | CDK2 (0.56) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL29426182 | 0.76 | CDK2 (0.56) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL27897027 | 0.73 | CDK2 (0.44) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL4140683 | 0.72 | P2RX7 (0.42) | P2RX7LMNATP53CDK1PDE8A | |
| SCHEMBL30148781 | 0.72 | CDK1 (0.41) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL1913380 | 0.72 | CDK1 (0.41) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL946328 | 0.71 | ADORA2A (0.50) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL30331956 | 0.71 | ADORA2A (0.50) | P2RX7CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL1355050 | 0.69 | P2RX7 (0.48) | P2RX7LMNATP53PDE8ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059418-A1 | SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2010-05-27 | — | — | WO | disclosed |