Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416884 | 0.86 | FPR2 (0.41) | HCRTR1HCRTR2PDE4BFPR2GRM5 | |
| SCHEMBL3411921 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3415419 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3409379 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3409382 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2926675 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2931039 | 0.78 | HCRTR2 (0.39) | HCRTR1HCRTR2PDE4BGRM5 | |
| SCHEMBL3413130 | 0.78 | HCRTR1 (0.40) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL2931852 | 0.78 | HCRTR1 (0.40) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL2056738 | 0.78 | HCRTR1 (0.43) | HCRTR1HCRTR2FPR2GRM5SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |