Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.62 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.62 |
| ▸ | HTR6 | P50406 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 12/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408350 | 0.93 | DRD2 (0.62) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL253399 | 0.82 | DRD2 (0.71) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL252277 | 0.81 | DRD2 (0.67) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3418478 | 0.81 | DRD2 (0.72) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3402211 | 0.79 | DRD2 (0.73) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL252996 | 0.78 | DRD2 (0.67) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL16633520 | 0.78 | DRD2 (0.59) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL252531 | 0.78 | DRD2 (0.72) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL252551 | 0.77 | DRD2 (0.71) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL254909 | 0.77 | DRD2 (0.72) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |