⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1035316 | 0.79 | TSHR (0.30) | — | |
| SCHEMBL1036695 | 0.77 | PHF8 (0.35) | — | |
| SCHEMBL6675712 | 0.74 | — | — | |
| SCHEMBL8503194 | 0.74 | — | — | |
| SCHEMBL1036915 | 0.72 | PHF8 (0.32) | — | |
| SCHEMBL1219938 | 0.72 | — | — | |
| SCHEMBL8077054 | 0.70 | HDAC3 (0.52) | — | |
| SCHEMBL13930299 | 0.70 | MCL1 (0.44) | — | |
| SCHEMBL31271973 | 0.69 | HDAC3 (0.33) | — | |
| SCHEMBL3258299 | 0.69 | CRBN (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929233-A | HALOGENATION OF ALLENYL BETA-LACTAM IN PRESENCE OF SULFINATE ION OR THIOLATE ION CAPTURING AGENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1999-07-27 | — | — | US | claimed |
| US-11629147-B2 | Triazolo-pyrimidine compounds and uses thereof | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-04-18 | — | — | US | disclosed |
| US-20210009600-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2021-01-14 | — | — | US | disclosed |
| US-10858365-B2 | Triazolo-pyrimidine compounds and uses thereof | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2020-12-08 | — | — | US | disclosed |
| US-20200331918-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2020-10-22 | — | — | US | disclosed |
| CN-107210212-B | Substrate processing method and substrate processing apparatus | 株式会社斯库林集团 | 2020-10-16 | — | — | CN | disclosed |
| EP-3689142-A1 | 1-(SUBSTITUTED-BENZOYL)-5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES | Adama Makhteshim Ltd. (IL) | 2020-08-05 | — | — | EP | disclosed |
| US-9271497-B2 | 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one derivatives | DOW AGROSCIENCES LLC (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150342188-A1 | 1-(SUBSTITUTED-BENZOYL)-5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-12-03 | — | — | US | disclosed |
| WO-2010040059-A1 | NICOTINE-BASED COMPOUNDS USEFUL FOR ASYMMETRIC SYNTHESIS | NORTH CAROLINA STATE UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
| US-5969131-A | OR PRECURSORS; CHEMICAL INTERMEDIATES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-10-19 | — | — | US | disclosed |
| US-5708165-A | ISOMERIZATION IN SOLVENT OF CEPHALOSPORINS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0154528-B1 | ALKENE, ALKYNE OR CYCLOALKYLENE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-11 | — | — | EP | disclosed |