Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488880 | 0.82 | CSF1R (0.38) | METMAP4K3JAK2CCR4CSF1R | |
| SCHEMBL1823431 | 0.79 | MET (0.57) | METMAP4K3JAK2 | |
| SCHEMBL28632433 | 0.78 | CSF1R (0.40) | METMAP4K3JAK2CSF1R | |
| SCHEMBL15271269 | 0.74 | MET (0.38) | METMAP4K3JAK2EPHB4 | |
| SCHEMBL2426505 | 0.73 | MET (0.47) | MET | |
| SCHEMBL14812299 | 0.72 | MET (0.54) | METMAP4K3JAK2 | |
| SCHEMBL1582121 | 0.72 | MET (0.66) | METMAP4K3JAK2 | |
| SCHEMBL488720 | 0.72 | MET (0.66) | METMAP4K3JAK2 | |
| SCHEMBL29507219 | 0.72 | CSF1R (0.57) | METCCR4CSF1R | |
| SCHEMBL488752 | 0.72 | CSF1R (0.57) | METCCR4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |