Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.63 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419326 | 1.00 | S1PR1 (0.63) | S1PR1PPARGPPARARXRANR1H2 | |
| SCHEMBL3416601 | 0.92 | S1PR1 (0.53) | S1PR1PPARGPPARARXRANR1H2 | |
| SCHEMBL3416605 | 0.92 | S1PR1 (0.53) | S1PR1PPARGPPARARXRANR1H2 | |
| SCHEMBL3418738 | 0.90 | S1PR1 (0.62) | S1PR1PPARGPPARANPC1RAB9A | |
| SCHEMBL3418743 | 0.90 | S1PR1 (0.62) | S1PR1PPARGPPARANPC1RAB9A | |
| SCHEMBL4726495 | 0.87 | S1PR1 (0.66) | S1PR1PPARGPPARARXRAPPARD | |
| SCHEMBL3414272 | 0.86 | NPC1 (0.64) | S1PR1PPARGPPARANPC1RAB9A | |
| SCHEMBL3414279 | 0.86 | NPC1 (0.64) | S1PR1PPARGPPARANPC1RAB9A | |
| SCHEMBL3418794 | 0.85 | PPARG (0.47) | S1PR1PPARGPPARARXRANR1H2 | |
| SCHEMBL3418793 | 0.85 | PPARG (0.47) | S1PR1PPARGPPARARXRANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| EP-1394147-A1 | CARBOXYLIC ACID DERIVATIVE AND MEDICINE COMPRISING SALT OR ESTER OF THE SAME | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |