Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.62 |
| ▸ | CDK2 | P24941 | 4/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | MUSK | O15146 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.62 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 17/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | STAT5B | P51692 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217032 | 1.00 | JAK3 (0.62) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL30009943 | 1.00 | JAK3 (0.62) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL422361 | 0.90 | JAK3 (0.77) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL422468 | 0.90 | JAK3 (0.77) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL3420180 | 0.85 | JAK3 (0.53) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL29794832 | 0.83 | JAK2 (0.58) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL10027491 | 0.79 | JAK3 (0.58) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL3041951 | 0.79 | NTRK1 (0.69) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL2513814 | 0.78 | JAK3 (0.59) | JAK3NTRK1CDK2FLT3LCK | |
| SCHEMBL588730 | 0.77 | NTRK1 (0.73) | JAK3NTRK1FLT3LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072238-A1 | FEEDER-BASED AND FEEDER-FREE STEM CELL CULTURE SYSTEMS FOR STRATIFIED EPITHELIAL STEM CELLS, AND USES RELATED THERETO | UNIVERSITY OF HOUSTON SYSTEM (US) | 2021-04-15 | — | — | WO | disclosed |
| EP-2164490-A1 | PYRAZOLYL DERIVATIVES WITH ANALGESIC ACTIVITY AND THEREFORE USEFUL IN THE TREATMENT OR PROPHYLAXIS OF PAIN. | AstraZeneca AB (SE) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008054292-A1 | PYRAZOLYL DERIVATIVES WITH ANALGESIC ACTIVITY AND THEREFORE USEFUL IN THE TREATMENT OR PROPHYLAXIS OF PAIN. | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |