Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 4/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ADH1B | P00325 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95877 | 0.81 | SLC6A2 (0.47) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| Benzylamine SCHEMBL27587164 | 0.72 | LOXL2 (0.54) | SLC6A2TAAR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3528108 | 0.71 | SLC6A2 (0.58) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| SCHEMBL28101753 | 0.70 | SLC6A2 (0.44) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| SCHEMBL11608630 | 0.70 | SMN1; SMN2 (0.48) | PPARGPPARAALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL28416740 | 0.70 | TAAR1 (0.52) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| SCHEMBL96457 | 0.70 | TAAR1 (0.52) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| SCHEMBL2398268 | 0.70 | SMN1; SMN2 (0.42) | SLC6A2TAAR1LMNACYP2D6ALDH1A1 | |
| SCHEMBL8398942 | 0.69 | SLC6A2 (0.56) | SLC6A2TAAR1LMNACYP2D6PPARG | |
| Ammonia Solution, Strong SCHEMBL28028790 | 0.69 | SLC6A2 (0.56) | SLC6A2TAAR1LMNACYP2D6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662977-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SIGNALRX PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
| US-7396828-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1611119-A1 | PI-3 KINASE INHIBITOR PRODRUGS | Semafore Pharmaceuticals, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6949537-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2005-09-15 | — | — | US | disclosed |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004089925-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | SLC6A2 1765/4885TAAR1 2560/4885LMNA 3669/4885 |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | PI4KA, PI4KB, PI4K2B | SLC6A2 1765/4885TAAR1 2560/4885LMNA 3669/4885 |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | SLC6A2 1765/4885TAAR1 2560/4885LMNA 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.