Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.50 |
| ▸ | CASR | P41180 | 16/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418275 | 0.92 | NR1I2 (0.51) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3419476 | 0.90 | NR1I2 (0.54) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3418570 | 0.89 | NR1I2 (0.48) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3414416 | 0.89 | NR1I2 (0.58) | NR1I2CASRHDAC6ALDH1A1LMNA | |
| SCHEMBL3421350 | 0.89 | NR1I2 (0.63) | NR1I2CASRHDAC6 | |
| SCHEMBL3420836 | 0.86 | NR1I2 (0.50) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3349521 | 0.85 | CASR (0.61) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3419845 | 0.84 | NR1I2 (0.52) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3345165 | 0.84 | CASR (0.56) | NR1I2CASRALDH1A1LMNACYP1A2 | |
| SCHEMBL3415872 | 0.83 | CASR (0.52) | NR1I2CASRALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065383-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-06-10 | — | — | WO | disclosed |