Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.37 |
| ▸ | ITGAL | P20701 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419095 | 0.83 | HTR2C (0.49) | FFAR1PTGS2PTGESARPOLB | |
| SCHEMBL15938770 | 0.83 | HTR2A (0.50) | FFAR1SLC9A1ITGB2ICAM1ITGAL | |
| SCHEMBL14892502 | 0.83 | FFAR1 (0.52) | FFAR1SLC9A1AR | |
| SCHEMBL3423257 | 0.83 | FFAR1 (0.52) | FFAR1SLC9A1AR | |
| SCHEMBL2963974 | 0.80 | CA1 (0.42) | FFAR1SLC9A1KDM4EALDH1A1HPGD | |
| SCHEMBL2957757 | 0.78 | FFAR1 (0.43) | FFAR1KDM4EALDH1A1HPGDAR | |
| SCHEMBL27363023 | 0.78 | FFAR1 (0.50) | FFAR1KDM4EALDH1A1HPGDAR | |
| SCHEMBL12875725 | 0.76 | SLC9A1 (0.62) | FFAR1SLC9A1PTGS2POLB | |
| SCHEMBL7000314 | 0.76 | SLC9A1 (0.62) | FFAR1SLC9A1PTGS2POLB | |
| SCHEMBL3422742 | 0.76 | SLC9A1 (0.62) | FFAR1SLC9A1PTGS2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714136-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-20090258873-A1 | Novel tetrahydropyridothiophenes | PEKARI KLAUS | 2009-10-15 | — | — | US | disclosed |
| US-20080206258-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080206258-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | FFAR1 3294/4885SLC9A1 4718/4885ITGB2 3537/4885 |
| US-20090258873-A1 | Novel tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | FFAR1 3410/4885SLC9A1 4724/4885ITGB2 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.