Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13092157 | 0.77 | HTT (0.48) | EPHX2P2RX7TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7921872 | 0.76 | EPHX2 (0.50) | EPHX2MMP1MMP2MMP9MMP8 | |
| SCHEMBL7919565 | 0.76 | EPHX2 (0.50) | EPHX2MMP1MMP2MMP9MMP8 | |
| SCHEMBL4030902 | 0.74 | CACNA2D1 (0.41) | HTT | |
| SCHEMBL4028935 | 0.68 | HTT (0.55) | EPHX2P2RX7TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL191727 | 0.68 | HTT (0.60) | EPHX2TAS1R3TAS1R1TAS1R2SMN1; SMN2 | |
| SCHEMBL3421659 | 0.68 | HTT (0.60) | EPHX2TAS1R3TAS1R1TAS1R2SMN1; SMN2 | |
| SCHEMBL191726 | 0.68 | HTT (0.60) | EPHX2TAS1R3TAS1R1TAS1R2SMN1; SMN2 | |
| SCHEMBL7154380 | 0.66 | ALDH1A1 (0.64) | EPHX2TAS1R3TAS1R1TAS1R2HTT | |
| SCHEMBL21766236 | 0.66 | ALDH1A1 (0.64) | EPHX2TAS1R3TAS1R1TAS1R2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2228065-A2 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-09-15 | — | — | EP | disclosed |