Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 7/20 | 0.75 |
| ▸ | MEN1 | O00255 | 7/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.75 |
| ▸ | STAT3 | P40763 | 3/20 | 0.62 |
| ▸ | GRM5 | P41594 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423513 | 0.94 | ALDH1A1 (0.67) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3420143 | 0.90 | ALDH1A1 (0.69) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3420284 | 0.86 | MAPT (0.80) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL13337753 | 0.85 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3419372 | 0.85 | ALDH1A1 (0.74) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL13337747 | 0.85 | ALDH1A1 (0.63) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3421633 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3421336 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3418041 | 0.84 | ALDH1A1 (0.78) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3420092 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714134-B2 | Compounds and use of tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-7714134-B2 | Compounds and use of tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-7714134-B2 | Compounds and use of tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-08-20 | — | — | US | disclosed |
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-08-20 | — | — | US | disclosed |
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-08-20 | — | — | US | disclosed |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | RB1, MCL1, CCAR2 | ALDH1A1 935/4885MAPT 1694/4885MEN1 3560/4885 |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | RB1, BAX, BCL2 | ALDH1A1 412/4885MAPT 2055/4885MEN1 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.