Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.73 |
| ▸ | FLT3 | P36888 | 13/20 | 0.73 |
| ▸ | KIT | P10721 | 10/20 | 0.73 |
| ▸ | CSF1R | P07333 | 5/20 | 0.73 |
| ▸ | FLT1 | P17948 | 5/20 | 0.73 |
| ▸ | FLT4 | P35916 | 4/20 | 0.73 |
| ▸ | LCK | P06239 | 3/20 | 0.73 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | LYN | P07948 | 3/20 | 0.59 |
| ▸ | BLK | P51451 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419771 | 0.84 | KDR (1.00) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL24799848 | 0.84 | KDR (0.81) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL422047 | 0.82 | KDR (0.81) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL423660 | 0.82 | KDR (0.81) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21386469 | 0.81 | KDR (0.79) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL419859 | 0.80 | KDR (0.79) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL421208 | 0.79 | KDR (1.00) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13523212 | 0.77 | KDR (0.82) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21668631 | 0.77 | KDR (0.72) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL28428802 | 0.77 | KDR (0.72) | KDRFLT3KITCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |