Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423918 | 1.00 | HDAC1 (0.47) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3144911 | 0.84 | HDAC1 (0.62) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3144918 | 0.84 | HDAC1 (0.62) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3137563 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3137574 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3140357 | 0.77 | HDAC1 (0.56) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3140370 | 0.77 | HDAC1 (0.56) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3846809 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3846814 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL3135363 | 0.74 | HDAC1 (0.73) | HDAC1HDAC6HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666868-B2 | e.g. N-Hydroxy-3-{1-[4-(1-methyl-1H-indol-5-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide; antiproliferative, anticarcinogenic, antiinflammatory, neuroleptic agent, autoimmune disorders | 4SC AG (DE) | 2010-02-23 | — | — | US | disclosed |