SCHEMBL3425341

SCHEMBL3425341

CC(C)(C)OC(=O)NC(O)(Cc1ccccc1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA7 P43166 1/20 0.49
CA14 Q9ULX7 1/20 0.49
AKT1 P31749 3/20 0.47
CTSS P25774 6/20 0.46
CTSK P43235 3/20 0.46
CTSL P07711 3/20 0.46
CTSB P07858 3/20 0.46
PPARA Q07869 2/20 0.45
PPARG P37231 1/20 0.45
SYK P43405 1/20 0.45
ATM Q13315 1/20 0.45
ACE P12821 1/20 0.44
IDO1 P14902 1/20 0.44
ALDH1A1 P00352 2/20 0.43
RECQL P46063 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22059597 1.00 CA12 (0.49) CA12CA1CA7CA14AKT1
Water SCHEMBL27509394 0.98 CTSS (0.48) CA12CA1CA7CA14AKT1
SCHEMBL9218191 0.85 CA12 (0.50) CA12CA1CA7CA14AKT1
SCHEMBL8951255 0.85 CA12 (0.50) CA12CA1CA7CA14AKT1
SCHEMBL6342947 0.85 CA12 (0.50) CA12CA1CA7CA14AKT1
SCHEMBL27903264 0.84 CA12 (0.51) CA12CA1CA7CA14AKT1
SCHEMBL27903266 0.84 CA12 (0.51) CA12CA1CA7CA14AKT1
SCHEMBL27903265 0.84 CA12 (0.51) CA12CA1CA7CA14AKT1
SCHEMBL2711160 0.83 CA12 (0.50) CA12CA1CA7CA14AKT1
SCHEMBL1552723 0.83 CA12 (0.50) CA12CA1CA7CA14AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2247582-A2 CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING SAME Aventis Pharma S.A. (FR) 2010-11-10 EP claimed
WO-2009115655-A2 CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING SAME AVENTIS PHARMA S.A. (FR) 2009-09-24 WO claimed
EP-2791122-A1 CRYSTALLINE FORM OF CABAZITAXEL AND PROCESS FOR PREPARING THE SAME Aventis Pharma S.A. (FR) 2014-10-22 EP disclosed
WO-2013088335-A1 CRYSTALLINE FORM OF CABAZITAXEL AND PROCESS FOR PREPARING THE SAME AVENTIS PHARMA S.A. (FR) 2013-06-20 WO disclosed
WO-2010128258-A1 ANTITUMOR COMBINATION INCLUDING CABAZITAXEL AND CAPECITABINE SANOFI-AVENTIS (FR) 2010-11-11 WO disclosed
EP-1694660-A1 PROCESS FOR THE PREPARATION OF ANHYDROUS AND HYDRATED ACTIVE PHARMACEUTICAL INGREDIENTS (APIS); STABLE PHARMACEUTICAL COMPOSITIONS PREPARED FROM THE SAME AND USES OF SAID COMPOSITIONS Quiral Quimica Do Brasil (BR) 2006-08-30 EP disclosed
EP-1140064-B1 ORAL ADMINISTRATION OF TAXOID DERIVATIVES AVENTIS PHARMA SA (FR) 2006-02-15 EP disclosed
WO-2005061474-A1 PROCESS FOR THE PREPARATION OF ANHYDROUS AND HYDRATED ACTIVE PHARMACEUTICAL INGREDIENTS (APIS); STABLE PHARMACEUTICAL COMPOSITIONS PREPARED FROM THE SAME AND USES OF SAID COMPOSITIONS QUIRAL QUÍMICA DO BRASIL (BR) 2005-07-07 WO disclosed
US-6403634-B1 FOR TREATING ABNORMAL CELL PROLIFERATION AVENTIS PHARMA S.A. (FR) 2002-06-11 US disclosed
US-6346543-B1 ADMINISTERING BACCATIN DERIVATIVE AS ANTICARCINOGENIC AGENT AVENTIS PHARMA S.A. (FR) 2002-02-12 US disclosed
EP-1140064-A2 ORAL ADMINISTRATION OF TAXOID DERIVATIVES Aventis Pharma S.A. (FR) 2001-10-10 EP disclosed
EP-1109547-A1 NEW USE OF TAXOID DERIVATIVES Aventis Pharma S.A. (FR) 2001-06-27 EP disclosed
EP-1105119-A2 NEW USE OF TAXOID DERIVATIVES Aventis Pharma S.A. (FR) 2001-06-13 EP disclosed
WO-2000041482-A2 ORAL ADMINISTRATION OF TAXOID DERIVATIVES AVENTIS PHARMA S.A. (FR) 2000-07-20 WO disclosed
EP-1020188-A1 New use of taxoid derivatives Aventis Pharma S.A. (FR) 2000-07-19 EP disclosed
WO-2000010547-A2 NEW USE OF TAXOID DERIVATIVES AVENTIS PHARMA S.A. (FR) 2000-03-02 WO disclosed
EP-0982028-A1 New use of taxoid derivatives Aventis Pharma S.A. (FR) 2000-03-01 EP disclosed
EP-0982027-A1 Taxoid derivatives for treating abnormal cell proliferation of the brain Aventis Pharma S.A. (FR) 2000-03-01 EP disclosed
WO-2000009120-A1 NEW USE OF TAXOID DERIVATIVES AVENTIS PHARMA S.A. (FR) 2000-02-24 WO disclosed