Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428160 | 0.89 | PTGDR2 (0.42) | MCHR1PTGDR2TBXA2RPTGDRPPARA | |
| SCHEMBL3397671 | 0.87 | CETP (0.36) | MCHR1PTGDR2TBXA2RPTGDRITGB1 | |
| SCHEMBL3434416 | 0.86 | PTGDR2 (0.40) | PTGDR2TBXA2RPTGDRITGB1ITGA4 | |
| SCHEMBL3430404 | 0.85 | PTGDR2 (0.47) | PTGDR2TBXA2RPTGDRITGB1ITGA4 | |
| SCHEMBL3406760 | 0.84 | CD274 (0.39) | MCHR1PTGDR2ITGB1ITGA4AKR1C3 | |
| SCHEMBL3429996 | 0.83 | ITGB1 (0.36) | PTGDR2TBXA2RPTGDRITGB1ITGA4 | |
| SCHEMBL3432089 | 0.83 | PTGDR2 (0.39) | PTGDR2TBXA2RPTGDRITGB1ITGA4 | |
| SCHEMBL15021367 | 0.83 | CASR (0.40) | LMNAPTGDR2TBXA2RPTGDRITGB1 | |
| SCHEMBL15021365 | 0.83 | CASR (0.40) | LMNAPTGDR2TBXA2RPTGDRITGB1 | |
| SCHEMBL3427454 | 0.82 | PTGDR2 (0.41) | MCHR1PTGDR2TBXA2RPTGDRPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245002-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009099901-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |