SCHEMBL3430404

SCHEMBL3430404

COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2)c1CN(Cc1ccccc1)C(C)=O

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 7/20 0.47
TBXA2R P21731 3/20 0.47
PTGDR Q13258 3/20 0.47
CETP P11597 6/20 0.44
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
PTGIR P43119 1/20 0.39
MTOR P42345 1/20 0.39
GPBAR1 Q8TDU6 1/20 0.38
PTGES O14684 1/20 0.38
ITGB1 P05556 1/20 0.38
ITGA4 P13612 1/20 0.38
MEN1 O00255 1/20 0.38
PKM P14618 1/20 0.38
KMT2A Q03164 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MTTP P55157 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3428160 0.89 PTGDR2 (0.42) PTGDR2TBXA2RPTGDRCETPCYP3A4
SCHEMBL3397671 0.87 CETP (0.36) PTGDR2TBXA2RPTGDRCETPITGB1
SCHEMBL3430527 0.86 PTGDR2 (0.61) PTGDR2TBXA2RPTGDRCETPCYP3A4
SCHEMBL3425673 0.85 MCHR1 (0.38) PTGDR2TBXA2RPTGDRCETPITGB1
SCHEMBL3432155 0.85 PTGDR2 (0.57) PTGDR2TBXA2RPTGDRCYP3A4CYP2C9
SCHEMBL3427902 0.82 PTGDR2 (0.47) PTGDR2TBXA2RPTGDRCYP3A4CYP2C9
SCHEMBL1361839 0.82 PTGDR2 (0.41) PTGDR2TBXA2RPTGDRCYP3A4CYP2C9
SCHEMBL3429996 0.81 ITGB1 (0.36) PTGDR2TBXA2RPTGDRCETPITGB1
SCHEMBL15021367 0.81 CASR (0.40) PTGDR2TBXA2RPTGDRCETPITGB1
SCHEMBL15021365 0.81 CASR (0.40) PTGDR2TBXA2RPTGDRCETPITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2257524-A1 N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Amira Pharmaceuticals, Inc. (US) 2010-12-08 EP disclosed
WO-2009099902-A1 N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS AMIRA PHARMACEUTICALS, INC. (US) 2009-08-13 WO disclosed