Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.56 |
| ▸ | JAK3 | P52333 | 20/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768361 | 0.81 | JAK2 (0.65) | JAK2JAK3 | |
| SCHEMBL12596475 | 0.78 | JAK2 (0.66) | JAK2JAK3FLT3 | |
| SCHEMBL21208764 | 0.78 | JAK2 (0.62) | JAK2JAK3 | |
| SCHEMBL13841846 | 0.76 | KDR (0.47) | JAK2JAK3 | |
| SCHEMBL12595855 | 0.75 | JAK2 (0.80) | JAK2JAK3FLT3 | |
| SCHEMBL12596465 | 0.75 | JAK2 (0.62) | JAK2JAK3FLT3 | |
| SCHEMBL8836423 | 0.75 | PTGS2 (0.59) | JAK2JAK3FLT3 | |
| SCHEMBL1762246 | 0.74 | JAK2 (0.61) | JAK2JAK3FLT3 | |
| SCHEMBL16404558 | 0.74 | JAK2 (0.61) | JAK2JAK3FLT3 | |
| SCHEMBL1762118 | 0.74 | JAK2 (0.51) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252618-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009085913-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-09 | — | — | WO | disclosed |