Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 8/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436117 | 0.85 | NR1I3 (0.45) | CYP19A1NR1I3NR1I2CDC7CYP1A2 | |
| SCHEMBL3405930 | 0.84 | DHODH (0.48) | ALDH1A1LMNACYP19A1GABRA2GABRB2 | |
| SCHEMBL3431149 | 0.84 | EGLN1 (0.53) | NR1I3 | |
| SCHEMBL3400568 | 0.80 | CYP19A1 (0.46) | ALDH1A1CYP19A1CDC7GABRA2GABRB2 | |
| SCHEMBL16929707 | 0.80 | EGLN1 (0.48) | NR1I3 | |
| SCHEMBL3404100 | 0.79 | PTPN11 (0.48) | ALDH1A1GABRA2GABRB2HPGDSMN1; SMN2 | |
| SCHEMBL3402159 | 0.78 | TARBP2 (0.47) | ALDH1A1LMNACYP19A1GABRA2GABRB2 | |
| SCHEMBL3401386 | 0.77 | TARBP2 (0.40) | ALDH1A1CYP19A1GABRA2GABRB2CYP1A2 | |
| SCHEMBL3403511 | 0.77 | TARBP2 (0.46) | ALDH1A1CYP19A1GABRA2GABRB2CYP1A2 | |
| SCHEMBL2776878 | 0.77 | ALDH1A1 (0.52) | ALDH1A1LMNACYP19A1CDC7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9387200-B2 | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity | FIBROGEN, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150209336-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. | 2015-07-30 | — | — | US | disclosed |
| US-8952160-B2 | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity | FIBROGEN, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| EP-2252619-B1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN INC (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20100330199-A1 | ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. | 2010-12-30 | — | — | US | disclosed |
| EP-2252619-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | Fibrogen, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009089547-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100330199-A1 | ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | HIF1A, HIF1AN, EGLN3 | ALDH1A1 256/4885LMNA 4759/4885CYP19A1 1327/4885 |
| US-20150209336-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | HIF1A, HIF1AN, EGLN3 | ALDH1A1 284/4885LMNA 4752/4885CYP19A1 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.