Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.55 |
| ▸ | STAT6 | P42226 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554864 | 0.89 | MAPK10 (0.69) | MAPK10MAPK9MAPK8PTK2STAT6 | |
| SCHEMBL3427288 | 0.85 | MAPK10 (0.59) | MAPK10MAPK9MAPK8PTK2EGFR | |
| SCHEMBL3427282 | 0.82 | MAPK10 (0.80) | MAPK10MAPK9MAPK8PTK2EGFR | |
| SCHEMBL4565856 | 0.79 | MAPK10 (0.65) | MAPK10MAPK9MAPK8PTK2STAT6 | |
| SCHEMBL2472290 | 0.79 | STAT6 (0.72) | MAPK10MAPK9STAT6 | |
| SCHEMBL2479353 | 0.78 | MAPK10 (0.58) | MAPK10MAPK9MAPK8PTK2STAT6 | |
| SCHEMBL12886430 | 0.76 | ZAP70 (0.56) | MAPK10MAPK9PTK2STAT6EGFR | |
| SCHEMBL4554865 | 0.75 | MAPK10 (0.69) | MAPK10MAPK9MAPK8PTK2EGFR | |
| SCHEMBL12886412 | 0.75 | MAPK10 (0.55) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL12886390 | 0.74 | MAPK10 (0.70) | MAPK10MAPK9MAPK8PTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249650-A1 | ANILINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009105498-A1 | ANILINOPYRIDINES AS INHIBITORS OF FAK | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |