Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.56 |
| ▸ | INSR | P06213 | 3/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427285 | 0.89 | MAPK10 (0.61) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL4554865 | 0.84 | MAPK10 (0.69) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL3400844 | 0.83 | MAPK10 (0.85) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL3775588 | 0.83 | MAPK10 (0.86) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL1232888 | 0.82 | MAPK10 (1.00) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL3767760 | 0.80 | MAPK10 (0.80) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL4565856 | 0.80 | MAPK10 (0.65) | MAPK10MAPK9MAPK8PTK2EGFR | |
| SCHEMBL2472290 | 0.80 | STAT6 (0.72) | MAPK10MAPK9STAT6 | |
| SCHEMBL3781239 | 0.80 | MAPK10 (0.79) | MAPK10MAPK9MAPK8PTK2INSR | |
| SCHEMBL2479353 | 0.79 | MAPK10 (0.58) | MAPK10MAPK9MAPK8PTK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134689-A2 | INHIBITORS OF FOCAL ADHESION KINASE | The Scripps Research Institute (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008115369-A2 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | WO | disclosed |