Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423438 | 0.90 | KCNH2 (0.53) | KCNH2HTR1ADRD2DRD4KCNQ1 | |
| SCHEMBL633981 | 0.86 | KCNH2 (0.45) | KCNH2MCHR1HTR1ADRD2DRD4 | |
| SCHEMBL632837 | 0.86 | KCNH2 (0.45) | KCNH2MCHR1HTR1ADRD2DRD4 | |
| SCHEMBL3428079 | 0.84 | KCNH2 (0.43) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL3419619 | 0.79 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL3668001 | 0.78 | DRD4 (0.40) | KCNH2HTR1ADRD2DRD4CYP2C9 | |
| SCHEMBL633189 | 0.76 | KCNH2 (0.53) | KCNH2DRD2DRD4KCNQ1CACNA1C | |
| SCHEMBL633039 | 0.76 | KCNH2 (0.53) | KCNH2DRD2DRD4KCNQ1CACNA1C | |
| SCHEMBL633992 | 0.74 | NR3C2 (0.41) | KCNH2MCHR1HTR1AHTR1DHTR1B | |
| SCHEMBL633993 | 0.74 | NR3C2 (0.41) | KCNH2MCHR1HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |