Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425401 | 0.88 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL3423438 | 0.87 | KCNH2 (0.53) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL633085 | 0.87 | KCNH2 (0.43) | KCNH2SLC2A1KCNQ1CACNA1C | |
| SCHEMBL633042 | 0.87 | KCNH2 (0.43) | KCNH2SLC2A1KCNQ1CACNA1C | |
| SCHEMBL3427490 | 0.84 | KCNH2 (0.45) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL3396541 | 0.79 | KCNH2 (0.41) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL3668001 | 0.78 | DRD4 (0.40) | KCNH2 | |
| SCHEMBL3419619 | 0.77 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL592146 | 0.76 | GRM2 (0.39) | KCNH2 | |
| SCHEMBL590312 | 0.76 | GRM2 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |