Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13497137 | 0.88 | MEN1 (0.35) | KMT2AMEN1TLR4 | |
| SCHEMBL15463086 | 0.85 | CA1 (0.39) | KMT2AMEN1TLR4CA1CA2 | |
| SCHEMBL20969080 | 0.85 | CA1 (0.39) | KMT2AMEN1TLR4CA1CA2 | |
| SCHEMBL20969085 | 0.85 | CA1 (0.39) | KMT2AMEN1TLR4CA1CA2 | |
| SCHEMBL430135 | 0.80 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL448968 | 0.80 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL446437 | 0.80 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL9409590 | 0.73 | CA1 (0.34) | KMT2ACA1CA2CA4 | |
| SCHEMBL20562072 | 0.72 | MEN1 (0.37) | KMT2AMEN1 | |
| SCHEMBL22862061 | 0.70 | CA1 (0.37) | KMT2ACA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662750-B2 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-02-16 | — | — | US | disclosed |
| US-20050153366-A1 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153366-A1 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | RIPK4, RIPK2, ATRIP | KMT2A 4515/4885MEN1 4003/4885TLR4 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.