RIPK4

Receptor-interacting serine/threonine-protein kinase 4 · P57078 · RIPK4 on Sugi Atlas →

1,094 patent compounds predicted against RIPK4, 860 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL23113156	0.75	2/20
SCHEMBL23113157	0.75	2/20
SCHEMBL23113270	0.59	2/20
SCHEMBL14658203	0.52	2/20
SCHEMBL23113259	0.51	2/20
SCHEMBL23113397	0.48	2/20
Tg100-115 (SCHEMBL360279)	1.00	1/20
SCHEMBL20609709	1.00	1/20
Hydrochloric Acid (SCHEMBL23113341)	0.98	1/20
Hydrochloric Acid (SCHEMBL23113343)	0.98	1/20
Tg100-115 (SCHEMBL3537211)	0.97	1/20
Tg100-115 (SCHEMBL3539251)	0.97	1/20
Tg100-115 (SCHEMBL3539255)	0.97	1/20
SCHEMBL23113152	0.94	1/20
SCHEMBL23113535	0.87	1/20
SCHEMBL23113538	0.87	1/20
SCHEMBL23113475	0.85	1/20
SCHEMBL23113477	0.85	1/20
SCHEMBL23113523	0.85	1/20
SCHEMBL23113525	0.85	1/20

Clinical trials — most relevant to RIPK4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis	PHASE4	NOT_YET_RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Clinical and Genomic Responses to Open Heart Surgery	PHASE3	COMPLETED
Ursodeoxycholic Acid as add-on Therapy in Type 2 Diabetes Mellitus	PHASE2/PHASE3	UNKNOWN
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis	PHASE3	COMPLETED
TNFSF11 Inhibition and Fertility: a Prospective Study	PHASE2	COMPLETED
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response	PHASE2	UNKNOWN
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer	PHASE2	COMPLETED
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients	PHASE2	ACTIVE_NOT_RECRUITING
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study	PHASE1	UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
the Influence of Remote Ischemic Preconditioning on Inflammation During Human Endotoxemia	EARLY_PHASE1	COMPLETED
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage	nan	COMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning	nan	COMPLETED
Remote Ischemic Preconditioning to Prevent Contrast-Induced Kidney Injury in Diabetic Patients (PRINCES)	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Molecular Mechanism of Neutrophil Necroptosis and Its Roles in RA Pathogenesis	nan	UNKNOWN
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Immune Cell Response to Stimuli	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Autophagy Bladder Cancer	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Evaluation of CEMIP in Pancreatic Cancer	nan	UNKNOWN
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty	nan	SUSPENDED

Related proteins — ESM-2 sequence neighbours (a RIPK4 binder may also engage these)

Protein	Name	Similarity
Q9ERK0	—	0.993	Q9ERK0 →
JAK3	Tyrosine-protein kinase JAK3	0.992	landscape →
Q63746	—	0.992	Q63746 →
ANKK1	Ankyrin repeat and protein kinase domain-containing protein 1	0.992	landscape →
Q60629	—	0.990	Q60629 →
Q00495	—	0.989	Q00495 →
Q8K1R7	—	0.988	Q8K1R7 →
DAPK1	Death-associated protein kinase 1	0.988	landscape →
CSF1R	Macrophage colony-stimulating factor 1 receptor	0.988	landscape →
P97874	—	0.988	P97874 →
Q8BZ25	—	0.988	Q8BZ25 →
Q80YE7	—	0.987	Q80YE7 →
P70600	—	0.987	P70600 →
NFKB1	Nuclear factor NF-kappa-B p105 subunit	0.987	landscape →
TYK2	Non-receptor tyrosine-protein kinase TYK2	0.987	landscape →
Q8WXK4	—	0.987	Q8WXK4 →
Q91974	—	0.987	Q91974 →
Q7ZZC8	—	0.987	Q7ZZC8 →
Q9Z1E3	—	0.986	Q9Z1E3 →
Q63272	—	0.986	Q63272 →
P13369	—	0.986	P13369 →
Q08E43	—	0.986	Q08E43 →
Q9Z2P5	—	0.986	Q9Z2P5 →
Q5BIW4	—	0.986	Q5BIW4 →
Q4R544	—	0.985	Q4R544 →
Q63618	—	0.985	Q63618 →
RAPGEF3	Rap guanine nucleotide exchange factor 3	0.985	landscape →
O13147	—	0.985	O13147 →
Q9D738	—	0.985	Q9D738 →
P25799	—	0.985	P25799 →