Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL28415888 | 0.83 | ALDH1A1 (0.93) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL198844 | 0.83 | ALDH1A1 (0.93) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| SCHEMBL11950516 | 0.81 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| SCHEMBL4401024 | 0.81 | ALB (0.57) | ALDH1A1ALOX15KDM4EHMGB1HPGD | |
| Phthalic Acid SCHEMBL27655252 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL10731126 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL27876734 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL27443690 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL27329792 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL120005 | 0.80 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689233-B1 | BICYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2012-07-04 | — | — | EP | disclosed |
| US-7772234-B2 | 7-(2,4-Dichlorophenylamino)-8-fluoro-4-methyl-cinnoline-6-carboxylic acid (2-hydroxyethoxy)-amide; mitogen activated protein, extracellular signal regulated kinase, kinase inhibitor; cancer and inflammation | ARRAY BIOPHARMA INC. (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1689233-A4 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1689233-A2 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050130976-A1 | Bicyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005051302-A2 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130976-A1 | Bicyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, RAF1 | ALDH1A1 2018/4885ALOX15 1549/4885AKR1C3 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.