Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | ATM | Q13315 | 3/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 11/20 | 0.50 |
| ▸ | JAK2 | O60674 | 8/20 | 0.50 |
| ▸ | JAK1 | P23458 | 8/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342425 | 0.89 | PDE4B (0.70) | PDE4BKCNH2ATMATR | |
| SCHEMBL2107056 | 0.83 | JAK2 (0.72) | PDE4BKCNH2JAK3JAK2JAK1 | |
| SCHEMBL2773376 | 0.82 | PDE4B (1.00) | PDE4BJAK3JAK1 | |
| SCHEMBL13609371 | 0.78 | PDE4B (0.57) | PDE4BKCNH2ATMATRJAK3 | |
| SCHEMBL13870222 | 0.78 | PDE4B (0.62) | PDE4BJAK3JAK2JAK1TYK2 | |
| SCHEMBL17241615 | 0.75 | KCNH2 (0.67) | PDE4BKCNH2ATMATRJAK3 | |
| SCHEMBL4340262 | 0.75 | PDE4B (0.54) | PDE4BKCNH2ATMATRJAK3 | |
| SCHEMBL5962970 | 0.75 | PDE4B (0.64) | PDE4B | |
| SCHEMBL1561252 | 0.74 | PDE4B (1.00) | PDE4B | |
| SCHEMBL5963166 | 0.73 | PDE4B (0.54) | PDE4BJAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249646-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | claimed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | claimed |