Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428110 | 0.89 | PDE4B (0.69) | PDE4BKCNH2ATMATR | |
| SCHEMBL4340262 | 0.87 | PDE4B (0.54) | PDE4BKCNH2ATMATRAURKA | |
| SCHEMBL2773376 | 0.83 | PDE4B (1.00) | PDE4B | |
| SCHEMBL13609371 | 0.79 | PDE4B (0.57) | PDE4BKCNH2ATMATRHDAC3 | |
| SCHEMBL13870222 | 0.79 | PDE4B (0.62) | PDE4BHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5962970 | 0.76 | PDE4B (0.64) | PDE4B | |
| SCHEMBL17241414 | 0.75 | KCNH2 (0.55) | PDE4BKCNH2ATMATR | |
| SCHEMBL11395584 | 0.75 | CDK2 (0.43) | PDE4BAURKA | |
| SCHEMBL30906008 | 0.74 | PDE4B (0.47) | PDE4BKCNH2ATMHDAC3HDAC1 | |
| SCHEMBL27092996 | 0.74 | PDE4B (0.47) | PDE4BKCNH2ATMHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |