SCHEMBL3428173

SCHEMBL3428173

C1=Cc2c(Cc3ccc4cccc5c4c3C=CC5)ccc3cccc(c23)C1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.39
TSHR P16473 2/20 0.39
ALDH1A1 P00352 3/20 0.33
HPGD P15428 3/20 0.33
CYP1A2 P05177 2/20 0.33
HSD17B10 Q99714 2/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
KDM4E B2RXH2 2/20 0.32
TYMS P04818 1/20 0.32
CYP2C19 P33261 1/20 0.32
MTNR1A P48039 1/20 0.30
MTNR1B P49286 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27810723 0.87 CYP3A4 (0.37) CYP3A4TSHRALDH1A1HPGDCYP1A2
SCHEMBL27723897 0.87 CYP3A4 (0.37) CYP3A4TSHRALDH1A1HPGDCYP1A2
SCHEMBL4943924 0.84 CYP3A4 (0.35) CYP3A4TSHRMTNR1AMTNR1B
SCHEMBL27963069 0.83 MTNR1A (0.34) CYP3A4TSHRMTNR1AMTNR1B
SCHEMBL27852851 0.82 CYP3A4 (0.33) CYP3A4TSHRMTNR1AMTNR1B
SCHEMBL9371030 0.82 TDP1 (0.41) CYP3A4TSHRALDH1A1HPGDCYP1A2
Cyanate SCHEMBL28350323 0.82 CYP3A4 (0.33) CYP3A4TSHRKDM4EMTNR1AMTNR1B
SCHEMBL28193285 0.81 NSD2 (0.35) CYP3A4TSHRMTNR1AMTNR1B
SCHEMBL10542837 0.80 TSHR (0.43) CYP3A4TSHRALDH1A1HPGDCYP1A2
SCHEMBL28332685 0.79 KCNH2 (0.37) CYP3A4TSHRALDH1A1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6639101-B2 Catalytic thermal decomposition of carbamates using silicates (clays, zeolites) as catalysts REPSOL QUIMICA, S.A. (ES) 2003-10-28 US claimed
EP-0271914-B1 POLYESTERAMIDE WITH IMPROVED COMPRESSION SET THE DOW CHEMICAL COMPANY (US) 1992-01-08 EP claimed
US-4742152-A LOW TEMPERATURE AND LOW PRESSURE POLYMERIZATION OF 4,4/2,2,2-TRIFLUORO-1-PHENYLETHYLIDENE/BIPHTHALIC ACID AND AN AROMATIC DIAMINE; AEROSPACE COMPOSITES UNITED TECHNOLOGIES CORPORATION (US) 1988-05-03 US claimed
EP-2518044-B1 METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE MITSUI CHEMICALS INC (JP) 2016-04-13 EP disclosed
US-9000219-B2 Method for treatment of isocyanate residue, and method for treatment of carbonate MITSUI CHEMICALS, INC. (JP) 2015-04-07 US disclosed
EP-2518044-A1 METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE Mitsui Chemicals, Inc. (JP) 2012-10-31 EP disclosed
US-20120271067-A1 METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE MITSUI CHEMICALS, INC. 2012-10-25 US disclosed
EP-2254126-A1 Organogel for electrical cable insulating layer Nexans (FR) 2010-11-24 EP disclosed
EP-2254127-A1 Organogel for electrical cable insulating layer Nexans (FR) 2010-11-24 EP disclosed
EP-1160239-B1 Isocyanate production procedure REPSOL QUIMICA SA (ES) 2005-07-20 EP disclosed
US-6639101-B2 Catalytic thermal decomposition of carbamates using silicates (clays, zeolites) as catalysts REPSOL QUIMICA, S.A. (ES) 2003-10-28 US disclosed
EP-1160239-A2 Isocyanate production procedure REPSOL QUIMICA S.A. (ES) 2001-12-05 EP disclosed
EP-0154037-A2 Blends of aromatic-aliphatic polyamides and impact modifiers THE DOW CHEMICAL COMPANY (US) 1985-09-11 EP disclosed