Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 5/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143607 | 0.93 | ADRB2 (0.51) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL143350 | 0.85 | ADRB2 (0.49) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL115994 | 0.83 | ADRB2 (0.49) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL143608 | 0.82 | KCNH2 (0.33) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL116248 | 0.82 | ADRB2 (0.49) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13625889 | 0.81 | ADRB2 (0.50) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12836650 | 0.81 | ADRB2 (0.49) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL178629 | 0.79 | ADRB2 (0.46) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL114597 | 0.77 | ADRB2 (0.49) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL117166 | 0.76 | ADRB2 (0.45) | KCNH2ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |