Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156724 | 0.80 | MAPT (0.38) | CNR2SMN1; SMN2UTS2RTSHRPPARA | |
| SCHEMBL150643 | 0.78 | MAPT (0.38) | CNR2SMN1; SMN2UTS2RTSHRPPARA | |
| SCHEMBL3428621 | 0.77 | PTGDR2 (0.50) | CNR2MAPTPTGDR2CNR1ALDH1A1 | |
| SCHEMBL3426175 | 0.73 | PSEN1 (0.41) | UTS2RPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL153792 | 0.72 | ALDH1A1 (0.40) | CNR2SMN1; SMN2UTS2RTSHRPPARA | |
| SCHEMBL152980 | 0.72 | PTGDR2 (0.38) | UTS2RMAPTPTGDR2 | |
| SCHEMBL3433469 | 0.72 | PPARA (0.40) | SMN1; SMN2PTGESTSHRPPARAPPARG | |
| SCHEMBL3412764 | 0.72 | PTGDR2 (0.48) | CNR2PTGESMAPTPTGDR2CNR1 | |
| SCHEMBL154952 | 0.71 | ALDH1A1 (0.40) | CNR2SMN1; SMN2UTS2RTSHRPPARA | |
| SCHEMBL155332 | 0.71 | PTGDR2 (0.40) | PPARAMAPTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |