Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | BLVRB | P30043 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429039 | 0.87 | S1PR1 (0.39) | S1PR1S1PR4S1PR5S1PR3RORC | |
| SCHEMBL3426503 | 0.80 | S1PR1 (0.37) | FFAR4S1PR1S1PR4S1PR5MAOA | |
| SCHEMBL3427849 | 0.78 | S1PR1 (0.38) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL3426893 | 0.78 | S1PR1 (0.42) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL3740660 | 0.78 | S1PR1 (0.62) | FFAR4S1PR1S1PR4S1PR5MAOA | |
| SCHEMBL3427656 | 0.78 | S1PR1 (0.62) | FFAR4S1PR1S1PR4S1PR5MAOA | |
| SCHEMBL3749815 | 0.78 | S1PR1 (0.62) | FFAR4S1PR1S1PR4S1PR5MAOA | |
| SCHEMBL947699 | 0.77 | S1PR1 (0.59) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL3429641 | 0.77 | RAB9A (0.48) | S1PR1S1PR4S1PR5NPC1RAB9A | |
| SCHEMBL3425996 | 0.77 | S1PR1 (0.40) | S1PR1S1PR4S1PR5S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292233-A1 | DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | claimed |
| EP-2252615-A1 | DIHYDRO- 1H- PYRROLO [1,2-A]INDOL-1-YL CARBOXYLIC DERIVATIVES WHICH ACT AS S1P1 AGONISTS | Arena Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| US-20100292233-A1 | DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2009094157-A1 | DIHYDRO- 1H- PYRROLO [1,2-A] INDOL-1-YL CARBOXYLIC DERIVATIVES WHICH ACT AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292233-A1 | DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS | S1PR1, S1PR2, S1PR3 | FFAR4 54/4885S1PR1 1/4885S1PR4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.