SCHEMBL3429308

SCHEMBL3429308

O=[N+]([O-])c1ccc(Br)c2[nH]nnc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
MEN1 O00255 3/20 0.43
MAPT P10636 3/20 0.43
KMT2A Q03164 3/20 0.43
NOS1 P29475 3/20 0.43
CYP3A4 P08684 3/20 0.43
KDM4E B2RXH2 2/20 0.43
CYP1A2 P05177 2/20 0.43
TSHR P16473 2/20 0.43
CYP2C19 P33261 2/20 0.43
NOS2 P35228 2/20 0.43
BLM P54132 2/20 0.43
CYP2D6 P10635 2/20 0.43
ALOX15 P16050 1/20 0.43
MAPK1 P28482 1/20 0.43
CYP19A1 P11511 1/20 0.37
THRB P10828 1/20 0.35
HPGD P15428 1/20 0.35
APEX1 P27695 1/20 0.35
NOS3 P29474 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3725853 0.86 MAPT (0.42) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL11759765 0.80 MAPT (0.41) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL13318847 0.78 ERN1 (0.38) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL1681343 0.76 NOS1 (0.33) NOS1
SCHEMBL28729843 0.73 TDP1 (0.46) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL10627192 0.73 MAPT (0.46) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL2954502 0.73 MAPT (0.41) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL29577616 0.73 TDP1 (0.46) ALDH1A1MEN1MAPTKMT2ANOS1
SCHEMBL9172490 0.72 MAPT (0.45) ALDH1A1MEN1MAPTKMT2ANOS1
Silver SCHEMBL9172484 0.72 MAPT (0.45) ALDH1A1MEN1MAPTKMT2ANOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010063802-A1 3, 4-DI-SUBSTITUTED CYCLOBUTENE- 1, 2 -DIONES AS CXCR2 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2010-06-10 WO disclosed