Ketanserin

Ketanserin

SCHEMBL34294

O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 1.00
SLC18A2 Q05940 4/20 1.00
CYP3A4 P08684 3/20 1.00
HPGD P15428 3/20 1.00
SLC6A3 Q01959 3/20 1.00
ALDH1A1 P00352 2/20 1.00
CYP2C19 P33261 2/20 1.00
LMNA P02545 2/20 1.00
CYP1A2 P05177 2/20 1.00
HTR1A P08908 2/20 1.00
CYP2C9 P11712 2/20 1.00
DRD2 P14416 2/20 1.00
HTR2C P28335 2/20 1.00
KCNH2 Q12809 2/20 1.00
MEN1 O00255 1/20 1.00
MAPT P10636 1/20 1.00
ADRA2B P18089 1/20 1.00
ADRA2C P18825 1/20 1.00
DRD1 P21728 1/20 1.00
DRD4 P21917 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ketanserin SCHEMBL4862503 1.00 HTR2A (1.00) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL29361038 1.00 HTR2A (1.00) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL1532014 0.99 HTR2A (0.98) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL2030457 0.99 HTR2A (0.98) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL30028921 0.99 HTR2A (0.98) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL5614705 0.97 HTR2A (0.94) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Hydrochloric Acid SCHEMBL9870098 0.95 HTR2A (0.91) HTR2ASLC18A2CYP3A4HPGDSLC6A3
SCHEMBL25837175 0.94 HTR2A (0.89) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Butanserin SCHEMBL875652 0.94 HTR2A (0.89) HTR2ASLC18A2CYP3A4HPGDSLC6A3
Ketanserin SCHEMBL362930 0.94 CYP2D6 (1.00) HTR2ASLC18A2CYP3A4HPGDSLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21317 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624036-B2 Method of treating post-traumatic stress disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-12624037-B2 Method of treating agitation, aggressive behavior, and impulse control disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
EP-4725483-A1 COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE Université de Bordeaux (FR) 2026-04-15 EP claimed
US-20260077092-A1 INJECTABLE COLLAGEN IMPLANTS AND COMPOSITIONS AND RELATED SYSTEMS, AND METHODS OF PREPARATION AND USE THEREOF Miach Orthopaedics, Inc. (US) 2026-03-19 US claimed
US-20260077093-A1 INJECTABLE COLLAGEN IMPLANTS AND COMPOSITIONS AND RELATED SYSTEMS, AND METHODS OF PREPARATION AND USE THEREOF Miach Orthopaedics, Inc. (US) 2026-03-19 US claimed
US-20260077094-A1 INJECTABLE COLLAGEN IMPLANTS AND COMPOSITIONS AND RELATED SYSTEMS, AND METHODS OF PREPARATION AND USE THEREOF Miach Orthopaedics, Inc. (US) 2026-03-19 US claimed
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
US-20260027256-A1 INJECTABLE COLLAGEN IMPLANTS AND COMPOSITIONS AND RELATED SYSTEMS, AND METHODS OF PREPARATION AND USE THEREOF Miach Orthopaedics, Inc. (US) 2026-01-29 US claimed
EP-4680244-A1 SEROTONIN 5HT2A RECEPTOR ANTAGONIST FOR USE IN TREATING SIDE EFFECTS RESULTING FORM MU OPIOID RECEPTOR AGONIST OVERDOSE Norwegian University Of Life Sciences (NO) 2026-01-21 EP claimed
US-20260000641-A1 ISOTOPICALLY ENRICHED ANALOGS OF 5,6-METHYLENEDIOXY-2-AMINOINDANE (IMDAI) TERRAN BIOSCIENCES INC (US) 2026-01-01 US claimed
WO-1982003677-A1 JACKETED TANK HERMETIC DRAIN-BACK SOLAR WATER HEATING SYSTEM ALTAS CORP (US) 1982-10-28 WO claimed
EP-0060523-A1 Process for removing hydroperoxides and aldehydes from allyl-alkyl ether UNION CARBIDE CORPORATION (US) 1982-09-22 EP claimed
US-4335127-A POTENT SEROTONIN ANTAGONISTS JANSSEN PHARMACEUTICA, N.V. (BE) 1982-06-15 US claimed
EP-0044337-A1 IMPROVED CONTINUOUS CENTRIFUGAL MACHINE. WESTERN STATES MACHINE CO (US) 1982-01-27 EP claimed
WO-1981003037-A1 METHOD AND DEVICE FOR PNEUMATICALLY LAUNCHING THE WEFT YARN IN A QUILL OF A LOOM PROVIDED WITH SEVERAL QUILLS LINKA A 1981-10-29 WO claimed
WO-1981002114-A1 IMPROVED CONTINUOUS CENTRIFUGAL MACHINE WESTERN STATES MACHINE CO (US) 1981-08-06 WO claimed
WO-1980002833-A1 INFRARED BATCH LEVEL CONTROL FOR A GLASS FURNACE OWENS CORNING FIBERGLASS CORP (US) 1980-12-24 WO claimed
US-4145014-A Method and device for automatically positioning a flexible elongate member in a storage basket rotatable about a vertical axis INSTITUT FRANCAIS DU PETROLE (FR) 1979-03-20 US claimed
US-3956934-A Liquid level indicator for pressurized liquid container WHITE JOSEPH MONTAGUE 1976-05-18 US claimed
US-3958081-A Block cipher system for data security INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1976-05-18 US claimed