Butanserin

Butanserin

SCHEMBL875652

O=C(c1ccc(F)cc1)C1CCN(CCCCn2c(=O)[nH]c3ccccc3c2=O)CC1

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 5/20 0.89
CYP3A4 P08684 4/20 0.89
HPGD P15428 3/20 0.89
CYP1A2 P05177 3/20 0.89
HTR2C P28335 3/20 0.89
ALDH1A1 P00352 2/20 0.89
CYP2C19 P33261 2/20 0.89
LMNA P02545 2/20 0.89
HTR1A P08908 2/20 0.89
CYP2C9 P11712 2/20 0.89
DRD2 P14416 2/20 0.89
KCNH2 Q12809 2/20 0.89
MEN1 O00255 1/20 0.89
MAPT P10636 1/20 0.89
ADRA2B P18089 1/20 0.89
ADRA2C P18825 1/20 0.89
DRD1 P21728 1/20 0.89
DRD4 P21917 1/20 0.89
HTR1D P28221 1/20 0.89
HTR1B P28222 1/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ketanserin SCHEMBL34294 0.94 HTR2A (1.00) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL4862503 0.94 HTR2A (1.00) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL29361038 0.94 HTR2A (1.00) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL30028921 0.93 HTR2A (0.98) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL2030457 0.93 HTR2A (0.98) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL1532014 0.93 HTR2A (0.98) HTR2ACYP3A4HPGDCYP1A2HTR2C
Ketanserin SCHEMBL5614705 0.91 HTR2A (0.94) HTR2ACYP3A4HPGDCYP1A2HTR2C
Hydrochloric Acid SCHEMBL9870098 0.90 HTR2A (0.91) HTR2ACYP3A4HPGDCYP1A2HTR2C
SCHEMBL25837175 0.89 HTR2A (0.89) HTR2ACYP3A4HPGDCYP1A2HTR2C
SCHEMBL11015897 0.89 HTR2A (0.89) HTR2ACYP3A4HPGDCYP1A2HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4547250-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS Terran Biosciences Inc. (US) 2025-05-07 EP claimed
US-20250049748-A1 ANALOGS OF 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE TERRAN BIOSCIENCES INC (US) 2025-02-13 US claimed
US-20240197681-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-06-20 US claimed
EP-4313030-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS Terran Biosciences, Inc. (US) 2024-02-07 EP claimed
WO-2024006984-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS TERRAN BIOSCIENCES INC. (US) 2024-01-04 WO claimed
WO-2023115002-A1 ANALOGS OF 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE TERRAN BIOSCIENCES INC. (US) 2023-06-22 WO claimed
WO-2023107966-A1 SALT AND SOLID FORMS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND ANALOGS TERRAN BIOSCIENCES, INC. (US) 2023-06-15 WO claimed
WO-2023081403-A1 ISOTOPOLOGES, SALTS, CRYSTALLINE FORMS, STEREOISOMERS, OF METHYLONE AND ETHYLONE AND METHODS OF USE THEREOF TERRAN BIOSCIENCES INC. (US) 2023-05-11 WO claimed
WO-2022212854-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS TERRAN BIOSCIENCES INC. (US) 2022-10-06 WO claimed
CN-105636438-A Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof CHEN JIANHONG 2016-06-01 CN claimed
US-20110065703-A1 NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS VM THERAPEUTICS LLC 2011-03-17 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101677971-A The combination of 5-HT2A inverse agonist and antagonist and antipsychotic drug ACADIA PHARM INC 2010-03-24 CN claimed
EP-2134330-A2 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS Acadia Pharmaceuticals Inc. (US) 2009-12-23 EP claimed
US-20090053329-A1 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS ACADIA PHARMACEUTICALS, INC. (US) 2009-02-26 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
WO-2008116024-A2 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS ACADIA PHARMACEUTICALS INC. (US) 2008-09-25 WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250049748-A1 ANALOGS OF 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE PNMT, HNMT, COMT HTR2A 37/4885CYP3A4 242/4885HPGD 1831/4885
US-20240197681-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS HTR1A, HTR2A, HTR3A HTR2A 2/4885CYP3A4 2453/4885HPGD 1973/4885
US-20110065703-A1 NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS CACNA1G, CACNA1C, CACNA1B HTR2A 671/4885CYP3A4 4561/4885HPGD 2254/4885
US-20090053329-A1 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS HTR2A, HTR3A, HTR1A HTR2A 1/4885CYP3A4 809/4885HPGD 2287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.