Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372561 | 0.93 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3438501 | 0.93 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3372559 | 0.93 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3373056 | 0.90 | REN (0.66) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL8260513 | 0.90 | REN (0.66) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3375553 | 0.90 | REN (0.66) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3370962 | 0.86 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3370964 | 0.86 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3429494 | 0.86 | REN (0.51) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3372201 | 0.85 | REN (0.70) | RENADRA1AKCNH2HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |