Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227437 | 1.00 | MME (0.50) | MMEACECPB2 | |
| SCHEMBL2314507 | 1.00 | MME (0.50) | MMEACECPB2 | |
| SCHEMBL31367029 | 0.98 | MME (0.49) | MMEACECPB2 | |
| Hydrochloric Acid SCHEMBL9701337 | 0.98 | MME (0.49) | MMEACECPB2 | |
| SCHEMBL30530140 | 0.84 | MME (0.42) | MMEACECPB2 | |
| Bromobenzene SCHEMBL8220105 | 0.82 | ACE (0.56) | MMEACE | |
| SCHEMBL13489661 | 0.78 | GABRR1 (0.39) | MMEACE | |
| SCHEMBL16239106 | 0.78 | MME (0.44) | MMEACE | |
| SCHEMBL9743096 | 0.78 | MME (0.44) | MMEACE | |
| SCHEMBL607225 | 0.78 | MME (0.44) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 295 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-222606383-U | Continuous reaction device for 3-acetylmercapto-2-methylpropanoic acid | 重庆市化工研究院有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-116514693-B | Preparation method of captopril intermediate D-3-acetylmercapto-2-methylpropionic acid | 阜阳欣奕华制药科技有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-118807620-A | Synthesis device and method of 3-acetylthio-2-methylpropanoic acid | 重庆市化工研究院有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-116655512-A | Preparation process of captopril | 江苏阿尔法药业股份有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-116514693-A | Preparation method of captopril intermediate D-3-acetylmercapto-2-methylpropionic acid | 阜阳欣奕华制药科技有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-115873908-A | Method for generating captopril intermediate D-beta-acetylthioisobutyric acid through catalytic hydrolysis | 金达威生物技术(江苏)有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-111039838-B | Preparation method of 3-acetylmercapto-2-methylpropanoic acid | 杭州乐敦科技有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-111039838-A | Preparation method of 3-acetylmercapto-2-methylpropanoic acid | 杭州乐敦科技有限公司 | 2020-04-21 | — | — | CN | claimed |
| CN-102351768-A | Method for synthesizing captopril and ceptopril | UNIV ZHEJIANG TECHNOLOGY | 2012-02-15 | — | — | CN | claimed |
| US-5367091-A | Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent | MEDICHEM, S.A. (ES) | 1994-11-22 | — | — | US | claimed |
| US-5097043-A | Reaction of 3-acetylthio-2-methylpropionic acid with an optically active benzylamine | E. R. SQUIBB & SONS, INC. (US) | 1992-03-17 | — | — | US | claimed |
| EP-0105696-B1 | OPTICALLY ACTIVE N-SUBSTITUTED PHENYLALANINOLS AND USE THEREFOR | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-01-02 | — | — | EP | claimed |
| EP-0105696-A1 | Optically active N-substituted phenylalaninols and use therefor | Dainippon Pharmaceutical Co., Ltd. (JP) | 1984-04-18 | — | — | EP | claimed |
| US-4411836-A | HEATING IN PRESENCE OF FATTY OR AROMATIC ACID SALT OR TERTIARY AMINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-10-25 | — | — | US | claimed |
| US-4224457-A | Process for manufacturing optically active sulfur-containing carboxylic acid | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1980-09-23 | — | — | US | claimed |
| JP-6336473-A | — | — | None | — | — | JP | disclosed |
| JP-59059660-A | — | — | None | — | — | JP | disclosed |
| US-4154935-A | Halogen substituted mercaptoacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |