Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608824 | 0.85 | HDAC8 (0.60) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL3432240 | 0.84 | SYK (0.49) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL30344916 | 0.84 | PLAU (0.49) | PLAUBAZ2BBAZ2AHDAC1HDAC2 | |
| SCHEMBL4252165 | 0.80 | HDAC8 (0.43) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL6086178 | 0.79 | CDK4 (0.55) | PLAUCYP11B1CYP11B2POLB | |
| SCHEMBL30577034 | 0.79 | CDK4 (0.55) | PLAUCYP11B1CYP11B2POLB | |
| SCHEMBL11976835 | 0.79 | SLC22A12 (0.54) | HDAC8POLBBRD4KDM4EALDH1A1 | |
| SCHEMBL28565969 | 0.78 | PPARG (0.53) | LMNASMN1; SMN2POLB | |
| SCHEMBL28136347 | 0.75 | KDM4E (0.49) | BAZ2BBAZ2AHDAC1HDAC2HDAC10 | |
| SCHEMBL28568252 | 0.75 | MAPT (0.52) | HDAC1HDAC2HDAC10HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265590-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009129335-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-10-22 | — | — | WO | disclosed |