Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 5/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184130 | 1.00 | CYP1A2 (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19FGFR1 | |
| SCHEMBL2181319 | 0.96 | CHEK2 (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19FGFR1 | |
| SCHEMBL12411866 | 0.91 | CHEK2 (0.36) | CYP1A2CYP3A4CYP2C9CYP2C19CHEK2 | |
| SCHEMBL12411590 | 0.89 | CHEK2 (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19CHEK2 | |
| SCHEMBL12411614 | 0.86 | AMY1A (0.38) | CHEK2AMY1ADGAT2MMP2MMP3 | |
| SCHEMBL13658321 | 0.86 | JAK2 (0.40) | CHEK2AMY1AKDM4EMAPTHTT | |
| SCHEMBL2185287 | 0.86 | CHEK2 (0.38) | CYP1A2CYP3A4CYP2C9CYP2C19CHEK2 | |
| SCHEMBL2184178 | 0.85 | CHEK2 (0.36) | CHEK2AMY1AKDM4EMAPTHTT | |
| SCHEMBL2180942 | 0.85 | CHEK2 (0.36) | CYP1A2CYP3A4CYP2C9CYP2C19CHEK2 | |
| SCHEMBL2184182 | 0.85 | CHEK2 (0.36) | CHEK2AMY1AKDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265598-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | Sanofi-Aventis (FR) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |