Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423919 | 0.95 | PDE4B (0.54) | PDE4BLMNAMAPTTP53 | |
| SCHEMBL3428989 | 0.93 | PDE4B (0.56) | PDE4BLMNAMAPK1MAPTTP53 | |
| SCHEMBL13760350 | 0.92 | PDE4B (0.52) | PDE4BLMNATP53 | |
| SCHEMBL8011333 | 0.91 | PDE4B (0.54) | PDE4BMAPK1 | |
| SCHEMBL1362378 | 0.91 | PDE4B (0.54) | PDE4BLMNAMAPK1MAPT | |
| SCHEMBL1435171 | 0.91 | PDE4B (0.66) | PDE4BMAPK1 | |
| SCHEMBL3428603 | 0.89 | PDE4B (0.50) | PDE4B | |
| SCHEMBL8002776 | 0.88 | PDE4B (0.49) | PDE4BMAPK1 | |
| SCHEMBL7999785 | 0.88 | PDE4B (0.49) | PDE4BMAPK1 | |
| SCHEMBL3426832 | 0.87 | PDE4B (0.51) | PDE4BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249830-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |